Weight loss drugs have had a chokehold on Hollywood stars in recent years, and the latest Euphoria premiere appears to prove Ozempic culture is still alive and well.
The season three premiere was held on Tuesday at the TCL Chinese Theatre in Los Angeles, with chatter immediately erupting online about the cast’s appearances.
While many welcomed the new series with much excitement and fanfare, others expressed concerns about some of the seemingly shrinking actors.
Alexa Demie appeared to attract the most attention, as she looked very different while walking the red carpet.
The actress, 35, who plays Maddy Perez in the series, ditched her usual straight locks and dark eye makeup for a more fresh-faced look.
She channelled classic glamour in a plunging silver-and-black striped off-the-shoulder gown for the star-studded event.
Alexa Demie (pictured), Zendaya and Hunter Schafer all look VERY different at Euphoria season three premiere in Los Angeles on Wednesday night Alexis is pictured left in 2019, and right, in 2026
Despite praising her beauty, many fans online expressed concern over her new svelte figure and seemingly sunken cheeks. Pictured in 2019 (left) and 2026 (right)
Despite praising her beauty, many fans online expressed concern over her new svelte figure and seemingly sunken cheeks.
‘Ozempic?’ one person wrote as she walked the red carpet, while another added: ‘Is no one concerned about the Ozempic and weight loss?’
‘Stop [Ozempic]. It’s destroying people’s beauty,’ someone else said, as one user wrote: ‘Holy Ozempic.’
Meanwhile, Maude Apatow (Lexi Howard), Zendaya (Rue Bennett), and Hunter Schafer (Jules Vaughn) also showed off their transformations at the premiere.
The trio has changed drastically since the premiere of season one of the show in 2019, with Zendaya sporting a very short hairstyle and Hunter toning down her platinum dyed locks to a more natural blonde.
Meanwhile, Maude has also cut her hair into a short bob and dyed a darker hue.
Several of the show’s stars also appear to have hired new stylists, with Zendaya, Alexa, Hunter and Maude all wearing more fashion-forward looks.
The Euphoria stars were spotted having a blast at the premiere afterparty, held at Chateau Marmont, where they mingled with the rest of the cast.
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Zendaya has always been known for her slender look. However, she’s still had quite the transformation over the years. Pictured in 2019 (left) and 2026 (right)
Hunter Schafer also rocked a glowing new look as she stepped out on the red-carpet. Pictured in 2019 (left) and 2026 (right)
Photos of the gathering were shared online by Vogue magazine, with fans immediately flocking to the comments with ‘Ozempic’ accusations.
‘They all tiny skinny,’ and, ‘Everybody is losing weight like crazy,’ were some of the messages seen beneath the post.
‘Ozempic came loose on set,’ said someone else.
‘Everybody be Ozempic-in hard,’ added another.
‘Maude and Lily are having an Ozempic off,’ one user said, referring to Lily-Rose Depp who was seen posing with Maude at the event.
‘They gave them Ozempic to eat,’ someone commented, while another added: ‘Was the theme Ozempic?’
The proliferation of GLP-1 weight-loss medications has inspired a worrying new beauty standard among Hollywood A-listers.
The drug was originally designed to treat type 2 diabetes, but has since been hijacked by celebrities desperate to shed weight.
Meanwhile, Maude has also cut her hair into a short bob and dyed then a darker hue. Pictured in 2019 (left) and 2026 (right)
Former Euphoria star Barbie Ferreira allegedly has turned to weight loss jabs in an attempt to further her Hollywood career. Pictured in 2019 (left) and 2026 (right)
Rebel Wilson, Serena Williams and Oprah are some of the stars who have previously admitted to using the weight-loss jabs.
When taken in a high dose, combined with appropriate diet and exercise, semaglutides like Ozempic, Wegovy and Mounjaro can help people lose weight.
However, they have been known to be linked to some side effects, including vomiting and diarrhoea.
Rapid weight loss can also lead to severe long-term consequences such as the weakening of bones that become susceptible to breakage and even the loss of teeth.
